Epigenetic Regulation in the Nervous System,, J. David Sweatt
Автор: Yasui, Dag Название: Neuropsychiatric Disorders and Epigenetics ISBN: 0128002263 ISBN-13(EAN): 9780128002261 Издательство: Elsevier Science Рейтинг: Цена: 93200.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease.
Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development.
Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction
Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists
Extensive use of diagrams, illustrations, tables, and graphical abstracts for each section providing rapid assessment
Автор: Rozanov, Vsevolod Название: Stress and Epigenetics in Suicide ISBN: 012805199X ISBN-13(EAN): 9780128051993 Издательство: Elsevier Science Рейтинг: Цена: 46600.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Stress and Epigenetics in Suicidediscusses the central role of epigenetic modifications in suicidal behavior. As early-life stress and an individual's ability to cope with such stressors, combined with psychological factors, social factors, and existential and cognitive factors can predispose young people to suicidal behavior and put them at added risk of suicidal behavior later in life, this book provides readers with an overview of the neurobiology of stress, an introduction to the epigenetic changes induced by stress, and an understanding of how vulnerability and resilience to stress are built. . It integrates these mechanisms into a biobehavioral model of suicide based on epigenetic marks, gene-environment interactions, and other stressors. More importantly, it provides future direction for research and discusses potential interventions. . This book is an ideal and trusted resource for researchers and clinicians who are interested in learning how the environment can affect behavior through genetics, and for those seeking the development of new methods for suicide prevention.
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