Quality of Life Outcomes in Clinical Trials and Health-Care, Walters, S. J.
Название: Clinical Epidemiology The Essentials 5th Edition bu Fletcher MD MSc, Robert, Fletcher MD MSc, Suzanne W.,2014 ISBN: 1451144474 ISBN-13(EAN): 9781451144475 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 46850.00 T Наличие на складе: Невозможна поставка. Описание: Now in its Fifth Edition, Clinical Epidemiology: The Essentials is a comprehensive, concise, and clinically oriented introduction to the subject of epidemiology. Written by expert educators, this text introduces students to the principles of evidence-based medicine that will help them develop and apply methods of clinical observation in order to form accurate conclusions. The Fifth Edition includes more complete coverage of systematic reviews and knowledge management, as well as other key topics such as abnormality, diagnosis, frequency and risk, prognosis, treatment, prevention, chance, studying cases and cause.
Автор: David J. Spiegelhalter Название: Bayesian Approaches to Clinical Trials and Health-Care Evaluation ISBN: 0471499757 ISBN-13(EAN): 9780471499756 Издательство: Wiley Рейтинг: Цена: 70700.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: READ ALL ABOUT IT! David Spiegelhalter has recently joined the ranks of Isaac Newton, Charles Darwin and Stephen Hawking by becoming a fellow of the Royal Society. Originating from the Medical Research Council`s biostatistics unit, David has played a leading role in the Bristol heart surgery and Harold Shipman inquiries.
Автор: Plichta Название: Munros Statistical methods health care 6E ISBN: 1451187947 ISBN-13(EAN): 9781451187946 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 90370.00 T Наличие на складе: Поставка под заказ. Описание: This text provides students with a solid foundation for understanding data analysis and specific statistical techniques. Focusing on the most current and frequently used statistical methods in today's health care literature, the book covers essential material for a variety of program levels including in-depth courses beyond the basic statistics course. Well-organized, clear text discussions and great learning tools help students overcome the complexities and fully comprehend the concepts of this often intimidating area of study.
Автор: Fayers, Peter; Hays, Ron Название: Assessing Quality of Life in Clinical Trials ISBN: 0198527691 ISBN-13(EAN): 9780198527695 Издательство: Oxford Academ Рейтинг: Цена: 147840.00 T Наличие на складе: Невозможна поставка. Описание: Researchers in all clinical fields are fully aware of the importance of Quality of Life measurements in judging the efficacy of a given treatment. Psychological criteria play an important role in this evaluation. Assessing Quality of Life in Clinical Trials explores the current state of the art and illustrates the benefits and potential of health related quality of life assessment in clinical trials. It cover a wide range of analytical issues, emphasizing new and innovative approaches that are of practical and clinical importance. The book will have widespread appeal to clinical trialists and researchers from a wide range of specialties.
Автор: Fairclough Название: Design and Analysis of Quality of Life Studies in Clinical Trials, Second Edition ISBN: 1420061178 ISBN-13(EAN): 9781420061178 Издательство: Taylor&Francis Рейтинг: Цена: 148010.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Presents a range of solutions to analytic issues. This title reflects developments in methodology with coverage of mixture models and a dataset example. It implements examples using SAS and R code and incorporates a number of examples from real QoL clinical trials to illustrate design and analysis methods.
Accurate sample size calculation ensures that clinical studies have adequate power to detect clinically meaningful effects. This results in the efficient use of resources and avoids exposing a disproportionate number of patients to experimental treatments caused by an overpowered study.
Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research explains how to determine sample size for studies with correlated outcomes, which are widely implemented in medical, epidemiological, and behavioral studies.
The book focuses on issues specific to the two types of correlated outcomes: longitudinal and clustered. For clustered studies, the authors provide sample size formulas that accommodate variable cluster sizes and within-cluster correlation. For longitudinal studies, they present sample size formulas to account for within-subject correlation among repeated measurements and various missing data patterns. For multiple levels of clustering, the level at which to perform randomization actually becomes a design parameter. The authors show how this can greatly impact trial administration, analysis, and sample size requirement.
Addressing the overarching theme of sample size determination for correlated outcomes, this book provides a useful resource for biostatisticians, clinical investigators, epidemiologists, and social scientists whose research involves trials with correlated outcomes. Each chapter is self-contained so readers can explore topics relevant to their research projects without having to refer to other chapters.
Название: Modern Adaptive Randomized Clinical Trials ISBN: 1482239884 ISBN-13(EAN): 9781482239881 Издательство: Taylor&Francis Рейтинг: Цена: 163330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Is adaptive randomization always better than traditional fixed-schedule randomization? Which procedures should be used and under which circumstances? What special considerations are required for adaptive randomized trials? What kind of statistical inference should be used to achieve valid and unbiased treatment comparisons following adaptive randomization designs? Modern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects answers these questions and more. From novel designs to cutting-edge applications, this book presents several new and key developments in adaptive randomization. It also offers a fresh and critical look at a number of already-classical topics. Featuring contributions from statisticians, clinical trialists, and subject-matter experts in academia and the pharmaceutical industry, the text: Clarifies the taxonomy of the concept of adaptive randomization Discusses restricted, covariate-adaptive, response-adaptive, and covariate-adjusted response-adaptive (CARA) randomization designs, as well as randomized designs with treatment selection Gives an exposition to many novel adaptive randomization techniques such as brick tunnel randomization, targeted least absolute shrinkage and selection operator (LASSO)-based CARA randomization, multi-arm multi-stage (MAMS) designs, to name a few Addresses the issues of statistical inference following covariate-adaptive and response-adaptive randomization designs Describes a successful implementation of a single pivotal phase II/III adaptive trial in infants with proliferating hemangioma Explores some practical aspects of phase II dose-ranging studies and examines statistical monitoring and interim analysis issues in response-adaptive randomized clinical trials Modern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects covers a wide spectrum of topics related to adaptive randomization designs in contemporary clinical trials. The book provides a thorough exploration of the merits of adaptive randomization and aids in identifying when it is appropriate to apply such designs in practice.
Казахстан, 010000 г. Астана, проспект Туран 43/5, НП2 (офис 2) ТОО "Логобук" Тел:+7 707 857-29-98 ,+7(7172) 65-23-70 www.logobook.kz
