Автор: Yui-Wing Francis Lam Название: Pharmacogenomics, ISBN: 0123919185 ISBN-13(EAN): 9780123919182 Издательство: Elsevier Science Рейтинг: Цена: 77470.00 T Наличие на складе: Поставка под заказ. Описание: Includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. This book contains review questions for an analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward.
Автор: D. Mrazek Название: Psychiatric Pharmacogenomics ISBN: 0195367294 ISBN-13(EAN): 9780195367294 Издательство: Oxford Academ Рейтинг: Цена: 69690.00 T Наличие на складе: Невозможна поставка. Описание: Psychiatric Pharmacogenomics is a book written to help clinicians to use pharmacogenomic testing to improve the pharmacotherapy that they provide for their patients. It is designed to teach clinicians how to order pharmacogenomic tests and interpret the results. Clinical examples are used to underscore the specific indications for pharmacogenomic testing and to clarify the clinical usefulness of identifying atypical genotypes that result in problematic responses to medication. The first section of the book begins with a basic review of molecular genetics. Additionally, the book also includes an extensive glossary of technical terms associated with molecular genetics and pharmacogenomics. The clinical utility of pharmacogenomic testing is demonstrated throughout the book by describing the implications of genetic variations for the care of individual patients. The second section of the book is organized into fourteen chapters that each focus on the clinical implications of testing for specific genes for which variants have been associated with either therapeutic response or side effects of psychotropic medications. Each of these chapters is structured in the same manner and involves a description of the gene and its significant variants. Each chapter also includes one or more clinical vignettes. The third section of the book discusses the clinical usefulness of pharmacogenomic testing, ethical issues associated with pharmacogenomic testing, and provides predictions for the future development of more sophisticated pharmacogenomic testing. Features Specific clinical examples are used to underscore the range of indications for pharmacogenomic testing and to clarify the clinical usefulness of identifying atypical genotypes that result in problematic responses to mediations Includes technical information about the nature and extent of genetic variability A series of clinical vignettes are used to illustrate the clinical usefulness of ph
Название: Applying Pharmacogenomics in Therapeutics ISBN: 1466582677 ISBN-13(EAN): 9781466582675 Издательство: Taylor&Francis Рейтинг: Цена: 183750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Recent advances in high-throughput gene sequencing and other omics biotechnologies have served as a springboard for the field of pharmacogenomics. Pharmacogenomics is now generally accepted as the major determinant of variable drug safety, efficacy, and cost-effectiveness. Therefore, widespread use of pharmacogenomics for patient care has become a critical requirement. There is an unprecedented urgency for aspiring and practicing clinicians to become trained on how to interpret data from pharmacogenomic testing in preparation for the future of healthcare--i.e., personalized medicine.
Applying Pharmacogenomics in Therapeutics provides timely coverage of the principles, practice, and potential of pharmacogenomics and personalized medicine. Comprised of chapters contributed by well-established pharmacologists and scientists from US and Chinese academia and industry, this authoritative text:
Demonstrates how to apply the principles of pharmacogenomics and its biotechnologies in patient care
Depicts the use of genetic biomarkers in drug discovery and development, laboratory medicine, and clinical services
Describes the practice of pharmacogenomics in the treatment of cancers, cardiovascular diseases, neurologic and psychiatric disorders, and pulmonary diseases
Discusses the merging of pharmacogenomics and alternative medicine, as well as the integration of pharmacogenomics into pharmacoeconomics
Each chapter begins with the key concepts, followed by in-depth explorations of case reports or critical evaluations of genetic variants/biomarkers, and concludes with questions for self-examination.
Автор: Kalow Werner Название: Pharmacogenomics [2nd Ed] ISBN: 1574448781 ISBN-13(EAN): 9781574448788 Издательство: Taylor&Francis Цена: 214370.00 T Наличие на складе: Невозможна поставка. Описание: Reflecting the shift from genetics to genomics in the pharmaceutical sphere, this Second Edition traces the evolution of the science of pharmacogenetics and gathers research from the forefront of the field-spanning the most influential breakthroughs in molecular diagnostics, metabonomics, proteomics, bioinformatics, disease mapping, pharmacodynamics, and disease gene identification.
Автор: Bertino Joseph S Название: Pharmacogenomics an Introduction and Clinical Perspective ISBN: 0071741690 ISBN-13(EAN): 9780071741699 Издательство: McGraw-Hill Рейтинг: Цена: 88070.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Offers a coverage of all need-to-know topics, from individual molecules to systemic diseases, this book also provides an examination of the latest technologies that are constantly reshaping the field. It also includes general pharmacogenomics and pharmacogenetics concepts, including geneticvariation in signal transduction and targets.
Автор: Qing Yan Название: Pharmacogenomics in Drug Discovery and Development ISBN: 1617378259 ISBN-13(EAN): 9781617378256 Издательство: Springer Рейтинг: Цена: 153720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This comprehensive volume explores cutting-edge technologies used to pursue systems-based pharmacogenomics. Extensive chapters follow on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases.
Название: Pharmacogenomics ISBN: 1588294404 ISBN-13(EAN): 9781588294401 Издательство: Springer Рейтинг: Цена: 144410.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Expert researchers and physician/clinicians describe in detail the newest and most commonly used technologies today in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions.
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