Anti-Angiogenesis Drug Discovery And Development, Rahman,Atta-ur

Автор: Domenico Ribatti
Название: Angiogenesis and Anti-Angiogenesis in Hematological Malignancies
ISBN: 9402403051 ISBN-13(EAN): 9789402403053
Издательство: Springer
Рейтинг:
Цена: 104480.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Exploring the critical role of angiogenesis in tumor progression and metastasis, this book features the latest and most promising anti-angiogenesis molecules now being deployed in the battle against hematological malignancies such as leukemia and lymphoma.

Автор: Ribatti
Название: Angiogenesis and Anti-Angiogenesis in Hematological Malignancies
ISBN: 940178034X ISBN-13(EAN): 9789401780346
Издательство: Springer
Рейтинг:
Цена: 121890.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Exploring the critical role of angiogenesis in tumor progression and metastasis, this book features the latest and most promising anti-angiogenesis molecules now being deployed in the battle against hematological malignancies such as leukemia and lymphoma.

Автор: Mousa, Shaker
Название: Anti-Angiogenesis Strategies in Cancer Therapeutics
ISBN: 012802576X ISBN-13(EAN): 9780128025765
Издательство: Elsevier Science
Рейтинг:
Цена: 77470.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Anti-angiogenesis Strategies in Cancer Therapeutics provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences.

Название: Mechanisms of Angiogenesis
ISBN: 3764364599 ISBN-13(EAN): 9783764364595
Издательство: Springer
Рейтинг:
Цена: 174150.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The induction of blood vessel growth as part of an adaptive process can be either exaggerated, such as in tumors, or too slow, as in ischemic diseases of heart and brain. Therefore it is an interesting target for medical intervention. This volume presents a thorough reconsideration of our current knowledge of factors and principles involved in angiogenic processes. It proceeds from a "macroscopic " perspective through cellular and physical mechanisms to the molecular level . In the first part, angiogenesis in physiological as well as pathological processes is described with a focus on embryogenesis, the reproductive system and the growing heart. The second part deals with cellular and physical mechanisms leading to angiogenesis, and the  last part presents a deeper insight into molecular mechanisms of blood vessel growth, including knockout studies of essential angiogenic molecules, the identification of signaling steps in angiogenesis and the importance of cellular junctions.

Автор: Goldberg
Название: Regulation of Angiogenesis
ISBN: 3764353090 ISBN-13(EAN): 9783764353094
Издательство: Birkhauser Verlag AG
Цена: 238850.00 T
Наличие на складе: Нет в наличии.
Описание: This volume presents a comprehensive review of current understanding of angiogenesis and angiogenesis control. Topics covered include: important pro-angiogenic growth factors and their receptors; angiogenesis inhibitors; extracellular matrix factors; and the role of the fibrinolytic system.

Автор: Napoleone Ferrara
Название: Angiogenesis
ISBN: 0849328446 ISBN-13(EAN): 9780849328442
Издательство: Taylor&Francis
Рейтинг:
Цена: 224570.00 T
Наличие на складе: Нет в наличии.
Описание: Reviews the status of the clinical applications of angiogenic growth factors and inhibitors. This book explores various molecular and genetic findings on the regulation of angiogenesis. It discusses the results of clinical trials and identifies the pathological conditions that are likely to benefit from such treatments.

Автор: Dieter Marm?
Название: Tumor Angiogenesis
ISBN: 3319336711 ISBN-13(EAN): 9783319336718
Издательство: Springer
Рейтинг:
Цена: 512430.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This exhaustive work shows that new therapies using anti-angiogenic drugs are of particular importance because they can be used against many different types of cancer, as tumor angiogenesis seems to be involved in most if not all solid metastasizing malignancies. The first part of this book summarizes the knowledge acquired on the molecular entities that play a role in tumor angiogenesis and their mechanisms of action. Furthermore, the identification of molecular markers and their validation as predictive and/or prognostic tools is reviewed. In the second and most important part, the clinical applications of anti-angiogenic treatments are documented for a wide variety of tumors. In particular, the modes of combination with other targeted and/or cytotoxic cancer therapies are presented.

Автор: Reza Forough
Название: New Frontiers in Angiogenesis
ISBN: 9401782296 ISBN-13(EAN): 9789401782296
Издательство: Springer
Рейтинг:
Цена: 153720.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:

New Frontiers in Angiogenesis is a fresh and unconventional look at the field of angiogenesis. It focuses on provocative and cutting-edge topics in the field of angiogenesis. Each chapter will take the reader along on a journey into uncharted territories of angiogenesis. The volume starts with a comprehensive overview of the field and continues with topics that have been minimally explored. The topics deal with dynamics of vasculogenesis using imaging techniques, bone marrow-derived endothelial cell precursors as potential therapeutic tools, regulation of post-angiogenic vessel regression, vascular mimicry, design and construction of artificial vessels, bioengineering of angiogenesis, and lymphangiogenesis recapitulating angiogenesis in health and disease states. Each chapter is written by leading experts of the subjects. It is hoped that this volume will challenge all of us interested in the field of angiogenesis and cardiovascular biology, in particular those in academia and industries, to think "outside the box" and explore angiogenesis from a fresh angle. It is hoped that New Frontiers in Angiogenesis is thought provoking and serve as a road map for discovering new findings to help betterments of human health.

Автор: Figg
Название: Angiogenesis
ISBN: 0387715177 ISBN-13(EAN): 9780387715179
Издательство: Springer
Рейтинг:
Цена: 222850.00 T
Наличие на складе: Поставка под заказ.
Описание: Dr Judah Folkman (1933-2008) was considered the `father of angiogenesis`. Because of Folkman`s discovery and research, the possibilities of angiogenic therapy have broadened beyond cancer to many noncancerous diseases. This book presents a summary of tumor angiogenesis.

Автор: Domenico Ribatti
Название: The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis
ISBN: 9400791577 ISBN-13(EAN): 9789400791572
Издательство: Springer
Рейтинг:
Цена: 104480.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: 1. Introduction 2. Chorioallantoic membrane and its embryological origin 2.1. Morphology of chorioallantoic membrane blood and lymphatic vessels 2.2. A single blood sinus or a capillary plexus beneath the chorionic epithelium? 2.3. The chorioallantoic membrane vascular growth 3. Use of chorioallantoic membrane in the study of angiogenic molecules 3.1. Role of FGF-2 in chorioallantoic membrane vascularization 4. Use of chorioallantoic membrane in the study of antiangiogenic molecules 5. Use of chorioallantoic membranes in the study of tumor angiogenesis 5.1. Angiogenesis and antiangiogenesis in multiple myeloma 5.2. Angiogenesis and antiangiogenesis in human neuroblastoma 6. Use of chorioallantoic membrane in the study of tumor metastasis 6.1. Spontaneous metastasis models. 6.2. Experimental metastasis studies. 7. Other applications 7.1. In ovo and ex ovo methods 7.2. Use of chorioallantoic membrane in the study of tumor lymphangiogenesis 8. Different morphological techniques that can be used to study vascularization of the CAM and the genes involved. 9. Methods of quantifying the angiogenic response 10. Limitations of the chorioallantoic membrane assay 11. Other classical in vivo assays in comparison (advantages, disadvantages and limitations) with the chorioallantoic membrane 12. Concluding remarks Acknowledgments References

Автор: Abdel-Majid Khatib
Название: Regulation of Carcinogenesis, Angiogenesis and Metastasis by the Proprotein Convertases (PC`s)
ISBN: 9401780900 ISBN-13(EAN): 9789401780902
Издательство: Springer
Рейтинг:
Цена: 149060.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Convertases are widely expressed activating enzymes involved in various physiological and pathological processes. The purpose of this book is to provide detailed and updated information on the role of these molecules in cancer. This book is the first to summarize current knowledge about the importance of protein precursors maturation by the convertases in tumor progression, angiogenesis and metastasis. In each chapter, the importance of the convertases in the activation of various cancer-related molecules including growth factors, adhesion molecules and proteases is discussed. Also this book covers the role of some convertases in the clinical setting. The book will be of interest to basic researchers as well as clinicians. It will also interest those working in the cancer research area and the pharmaceutical industry, who are looking for new strategies in cancer therapy. Finally, this book is also a useful reference for researchers and clinicians pursuing research on growth factors, adhesion molecules, proteases and their implications in the processes of tumor progression, angiogenesis and metastasis.

Автор: William D. Figg; Judah Folkman
Название: Angiogenesis
ISBN: 1489996680 ISBN-13(EAN): 9781489996688
Издательство: Springer
Рейтинг:
Цена: 186330.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Dr. Judah Folkman, “father of angiogenesis”, (1933-2008) was the Director of the Vascular Biology Program, Andrus Professor of Pediatric Surgery, and Professor of Cell Biology at Harvard University's Boston Children's Hospital. In the 1971 issue of The New England Journal of Medicine, he proposed the theory that tumor growth is angiogenesis dependent. This premise was the basis of this field of research and has become the focus of scientists worldwide. Because of Folkman's discovery and research, the possibilities of antiangiogenic and angiogenic therapy have broadened beyond cancer to many noncancerous diseases. This book represents the first collection in a volume of which Dr. Folkman is co-editor. Dr. Folkman authored nearly 400 original papers and more than 100 book chapters. Dr. William Figg is the chief of the Molecular and Clinical Pharmacology Program at the National Cancer Institute, National Institutes of Health. Over the past 15 years, his laboratory and clinic at the NCI have focused on the development of angiogenesis inhibitors. Dr. Figg has published more than 380 publications.