Antibiotics and Antibiotic Resistance in the Environment, Amabile-Cuevas, Carlos F.

Автор: Hamao Umezawa; Irving R. Hooper; Y. Ito; Irving R.
Название: Aminoglycoside Antibiotics
ISBN: 3642685811 ISBN-13(EAN): 9783642685811
Издательство: Springer
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Цена: 121890.00 T
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Описание: With contributions by numerous experts

Автор: David M. Shlaes
Название: Antibiotics
ISBN: 9400795327 ISBN-13(EAN): 9789400795327
Издательство: Springer
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Цена: 130430.00 T
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Описание: Antibiotics are truly miracle drugs. As a class, they are one of the only ones that actually cure disease as opposed to most drugs that only help relieve symptoms or control disease. Since bacteria that cause serious disease in humans are becoming more and more resistant to the antibiotics we have today, and because they will ultimately become resistant to any antibiotic that we use for treatment or for anything else, we need a steady supply of new antibiotics active against any resistant bacteria that arise. However, the antibiotics marketplace is no longer attractive for large pharmaceutical companies, the costs of development are skyrocketing because of ever more stringent requirements by the regulatory agencies, and finding new antibiotics active against resistant strains is getting harder and harder. These forces are all combining to deny us these miracle drugs when we need them the most. I provide a number of possible paths to shelter from this perfect storm.

Автор: Landas, Marc
Название: Cold war resistance
ISBN: 1640121056 ISBN-13(EAN): 9781640121058
Издательство: Mare Nostrum (Eurospan)
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Цена: 33400.00 T
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Описание: In June 1941 a pair of British scientists boarded a plane for America with World War II raging all around them. They carried a precious commodity-penicillin-and the knowledge that it would change history. Once the U.S. government had been debriefed, the Office of Science Research and Development, in conjunction with British counterparts, assumed control, and penicillin became a top-secret matter of national security, second in importance only to the atomic bomb. In Cold War Resistance Marc Landas uncovers the dark history behind the discovery, production, and distribution of penicillin and other antibiotics. In 1949 the United States embargoed any material deemed of “strategic importance,” including antibiotics, from going to Communist countries, effectively shutting off the Soviet Union from a modern medical miracle. The Soviets responded by creating satellite antibiotic factories in Warsaw Pact countries that produced subpar antibiotics, which soon led to antibiotic resistance. Today, the number of effective antibiotics available is dwindling, and the state of antibiotic resistance is worsening. The Cold War played a critical role in fostering this resistance, as Landas argues in this pathbreaking history of the international struggle over antibiotics.  

Автор: W. Sch?nfeld; H.A. Kirst
Название: Macrolide Antibiotics
ISBN: 3034894384 ISBN-13(EAN): 9783034894388
Издательство: Springer
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Цена: 139750.00 T
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Описание: The following group of chapters cover the complex chemistry of the macro- lactone structures, giving historic background, basic structure-activity relation- ships of various derivatization strategies, and perspectives for future discovery of new semisynthetic macrolide antibiotics.

Автор: Alle Bruggink
Название: Synthesis of ?-Lactam Antibiotics
ISBN: 9401038511 ISBN-13(EAN): 9789401038515
Издательство: Springer
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Цена: 156720.00 T
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Описание: Process technology studies including new reactor concepts, possible short-cut routes and improved down-stream-processing methods complete a broad view on the scope and limitations of the presently developed industrial processes including an intriguing insight into future process possibilities.

Автор: Gabor Lukacs; Masaji Ohno
Название: Recent Progress in the Chemical Synthesis of Antibiotics
ISBN: 3642756190 ISBN-13(EAN): 9783642756191
Издательство: Springer
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Цена: 113190.00 T
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Описание: Although, the discovery of most of these agents came from more or less sophisticated screening programs of soil microrganisms, many of the important antibiotics used today in clinical practice are derived from the original biosynthetic products by the application of often novel and generally elaborated chemical synthetic methodologies.

Автор: Gabor Lukacs; H. Audrain; M. Bartra; A.K. Bose; C.
Название: Recent Progress in the Chemical Synthesis of Antibiotics and Related Microbial Products Vol. 2
ISBN: 3642782523 ISBN-13(EAN): 9783642782527
Издательство: Springer
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Цена: 113190.00 T
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Описание: The 1st Euchem Symposium on the Chemical Synthesis of Antibiotics was held in Aussois in Savoie, France on May 2-6, 1988 thanks to the efforts of Prof. G. Lukacs, chairperson, and Prof. F. Arcamone and Prof. P. Welzel, vice-chairpersons of the International Organizing Committee. Following the great success of the Ist Symposium, the 2nd Symposium, which was chaired by Prof. Ohno, was held in Oiso, Japan in 1990. The 3rd Symposium, chaired by Prof. K. Krohn, was held in Kloster Banz, Germany in 1992. It has been decided that the 4th Symposium will take place in the United States in 1994 and be chaired by Dr. H. A. Kirst of Lilly Research Laboratories. The Euchem Symposium has come to serve as an important symposium where one can understand the development and the future directions of the chemical synthesis of antibiotics and other bioactive metabolites from microorganisms. Prof. G. Lukacs, in cooperation with Prof. M. Ohno, edited the book "Recent Progress in the Chemical Synthesis of Antibiotics" three years ago. Most of its contributors were the participants of the Aussois Symposium. This book attracted the attention of researchers specializing in organic synthesis and stimulated considerable progress in this field.

Автор: Arya
Название: Aminoglycoside Antibiotics - From Chemical Biology to Drug Discovery
ISBN: 047174302X ISBN-13(EAN): 9780471743026
Издательство: Wiley
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Цена: 164680.00 T
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Описание: Advances that open new avenues in developing aminoglycoside antibiotics During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new therapeutic targets for intervention.

Автор: Sass
Название: Antibiotics
ISBN: 1493966324 ISBN-13(EAN): 9781493966325
Издательство: Springer
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Цена: 139750.00 T
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Описание: This volume provides state-of-the-art and novel methods on antibiotic isolation and purification, identification of antimicrobial killing mechanisms, and methods for the analysis and detection of microbial adaptation strategies. Antibiotics: Methods and Protocols guides readers through chapters on production and design, mode of action, and response and susceptibility. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Antibiotics: Methods and Protocols aims to inspire scientific work in the exciting field of antibiotic research.

Автор: Walsh
Название: Antibiotics: Challenges, Mechanisms, Opportunities
ISBN: 1555819303 ISBN-13(EAN): 9781555819309
Издательство: Wiley
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Цена: 109770.00 T
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Описание: Antibiotics: Challenges, Mechanisms, Opportunities details the contemporary challenges for discovery, optimization, and advancement of new antibiotics. It focuses on discovery not preclinical or clinical development. Given that the few classes of clinically significant antibiotics are all small molecules, this book focuses on the molecular structures and characteristics of both natural and synthetic antibacterial agents. Antibiotics is a valuable reference for microbiologists, bacterial physiologists, geneticists, pharmacologists, and drug developers. A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:  • What are antibiotics? • Where do antibiotics come from?• How do antibiotics work? • Why do antibiotics stop working? • How should our limited inventory of effective antibiotics be addressed?  Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.

Автор: Westley
Название: Polyether Antibiotics
ISBN: 0824718887 ISBN-13(EAN): 9780824718886
Издательство: Taylor&Francis
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Цена: 265410.00 T
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Описание: This collection of essays will stimulate the use of ionophores in different research areas. It includes information on potential breakthroughs in the halogenated derivatives of lasalocid and ethers of antibiotic A204A, polyethers and analytical techniques used to unravel their complex structures.

Автор: Conte
Название: Manual of Antibiotics and Infectious Diseases
ISBN: 0781723167 ISBN-13(EAN): 9780781723169
Издательство: Lippincott Williams & Wilkins
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Цена: 36610.00 T
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Описание: Manual of Antibiotics and Infectious Diseases: Treatment and Prevention was designed for health-care professionals involved in the daily care of patients with infectious diseases. The book covers antibiotics currently available, their doses, and their dose adjustments. It explains what to do when faced with renal failure, as well as empirical, prophylactic, and definitive antibiotic therapies--everything from bacteria resistance to AIDS therapies. A new section on hospital epidemiology and infection control is included in this Ninth Edition. A Brandon-Hill recommended title.