Mechanisms of Cell Death and Opportunities for Therapeutic Development, Liao, Diaqing

Автор: Pecorino, Lauren
Название: Molecular Biology of Cancer
ISBN: 0198833024 ISBN-13(EAN): 9780198833024
Издательство: Oxford Academ
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Цена: 74610.00 T
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Описание: Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students.

Автор: Dominguez-Villar
Название: PI3K and AKT Isoforms in Immunity
ISBN: 3031065654 ISBN-13(EAN): 9783031065651
Издательство: Springer
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Цена: 139750.00 T
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Описание: This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the body’s own and foreign antigens and diseases such as cancer and autoimmunity. This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases. This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.

Автор: Wilson Iii David M
Название: Base Excision Repair Pathway, The: Molecular Mechanisms And Role In Disease Development And Therapeutic Design
ISBN: 9814719722 ISBN-13(EAN): 9789814719728
Издательство: World Scientific Publishing
Цена: 274560.00 T
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Описание: This book will serve as the preeminent text book on the topic of "base excision repair", a key DNA repair pathway that protects cells from most spontaneous forms of DNA damage, including oxidative lesions that arise both in the nuclear and mitochondrial genomes.

Название: Inflammasome biology
ISBN: 0323918026 ISBN-13(EAN): 9780323918022
Издательство: Elsevier Science
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Цена: 151590.00 T
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Описание: 30 Old Testament Passages with Deeper Meaning invites everyday Bible readers to discover the greater depth in familiar verses. Michael Williams brings years of experience in explaining how often-overlooked cultural, linguistic, historical, and theological clues in ordinary biblical texts reveal deeper meaning for those who are made aware of them.

Автор: Marti, Amelia
Название: Telomeres, Diet and Human Disease
ISBN: 0367782049 ISBN-13(EAN): 9780367782047
Издательство: Taylor&Francis
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Цена: 48990.00 T
Наличие на складе: Нет в наличии.

Автор: Walsh
Название: Antibiotics: Challenges, Mechanisms, Opportunities
ISBN: 1555819303 ISBN-13(EAN): 9781555819309
Издательство: Wiley
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Цена: 109770.00 T
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Описание: Antibiotics: Challenges, Mechanisms, Opportunities details the contemporary challenges for discovery, optimization, and advancement of new antibiotics. It focuses on discovery not preclinical or clinical development. Given that the few classes of clinically significant antibiotics are all small molecules, this book focuses on the molecular structures and characteristics of both natural and synthetic antibacterial agents. Antibiotics is a valuable reference for microbiologists, bacterial physiologists, geneticists, pharmacologists, and drug developers. A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:  • What are antibiotics? • Where do antibiotics come from?• How do antibiotics work? • Why do antibiotics stop working? • How should our limited inventory of effective antibiotics be addressed?  Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.

Автор: Dmitry I. Gabrilovich; Arthur Andrew Hurwitz
Название: Tumor-Induced Immune Suppression
ISBN: 1489980555 ISBN-13(EAN): 9781489980557
Издательство: Springer
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Цена: 191560.00 T
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Описание: Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer and therapeutic approaches to their correction.

Автор: Chris H. De Bruyn
Название: Purine Metabolism in Man-IV
ISBN: 1468445553 ISBN-13(EAN): 9781468445558
Издательство: Springer
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Цена: 46570.00 T
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Описание: These two volumes, entitled "Purine Metabolism in Man IV" con- tain the paper presented at the "IV. Knowledge derived from the study of purine metabolism in relation to lymphocyte function, for instance, has opened up new possibilities for immunomodulation and leukaemia chemotherapy, with eventual conse- quences for other types of cancer.

Автор: Green Douglas R.
Название: Means to an End: Apoptosis and Other Cell Death Mechanisms
ISBN: 0879698888 ISBN-13(EAN): 9780879698881
Издательство: Неизвестно
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Цена: 33490.00 T
Наличие на складе: Невозможна поставка.
Описание: One million cells in our bodies die every secondthey commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various developmental processes and the immune system. In Means To An End, Douglas Green provides a clear and comprehensive view of apoptosis and other cell death mechanisms. Taking a bottom-up approach, he starts with the enzymes that perform the execution process (a family of proteases termed caspases) and examines their cellular targets and the ways in which they are activated. He then looks at the molecular machinery that links signals that cause cell death to caspases, emphasizing the importance of the BCL-2 family of proteins and the role of cytochrome c released from mitochondria. The final stage of the process, phagocytic removal of dead or dying cells, is also covered. Green outlines the roles of apoptosis and death mechanisms such as necrosis in embryogenesis, neuronal selection, and the development of self-tolerance in the immune system. In addition, he explains how cell death defends the body against cancer and traces the evolutionary origins of the apoptosis machinery back over a billion years. The book is thus of great use to all biologists interested in how cells function in the context of multicellular organisms and will appeal to everyone from undergraduates encountering the topic for the first time to researchers actively working in the field.

Автор: Fujikawa
Название: Acute Neuronal Injury
ISBN: 303008468X ISBN-13(EAN): 9783030084684
Издательство: Springer
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Цена: 93160.00 T
Наличие на складе: Поставка под заказ.
Описание: An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death.

Автор: Alvero Ayesha B., Mor Gil G.
Название: Detection of Cell Death Mechanisms: Methods and Protocols
ISBN: 1071611615 ISBN-13(EAN): 9781071611616
Издательство: Springer
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Цена: 158380.00 T
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Описание: This volume provides detailed protocols for the performance, analysis, and troubleshooting of in vitro and in vivo experiments related to programmed cell death. Chapters compile conventional techniques such as western blot and qPCR and state-of-the art transmission electron microscopy and real-time multiplexed imaging assays. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Detection of Cell Death Mechanisms: Methods and Protocols aims to ensure seamless execution of protocols on specific cell death type.

Автор: Mackay, Niki
Название: Detection of Cell Death Mechanisms
ISBN: 107161164X ISBN-13(EAN): 9781071611647
Издательство: Springer
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Цена: 121110.00 T
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Описание: This detailed book collects a variety of methods from investigators at the forefront of chondrocyte biology and pathology research that they have tailored for their research projects in order to tackle the unique properties and challenges of the chondrocyte and those of its tissue matrix.