Cutaneous Receptors, C. Chouchkov

Автор: Shukla, Arun K.
Название: G Protein-Coupled Receptors, Part B, 2nd Edition
ISBN: 0128133198 ISBN-13(EAN): 9780128133194
Издательство: Elsevier Science
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Цена: 156080.00 T
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Описание:

G Protein Coupled Receptors, Second Edition, Volume 143, a new volume in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. It contains a wide array of topics about the G protein coupled receptors, as well as updates of chapters from the first edition.

Автор: Rast
Название: Immune Receptors
ISBN: 1617791385 ISBN-13(EAN): 9781617791383
Издательство: Springer
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Цена: 135090.00 T
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Описание: Immunology has made significant progress in the past decade, driven forward by rapidly advancing technology and a renewed interest in the vast realm of innate immunity. The receptors that mediate these functions are at the front lines of both protective and regulative roles of the immune system.  In Immune Receptors: Methods and Protocols, expert researchers present a variety of experimental approaches to the characterization of immune receptors and the cell biology that mediates their functions.  These include imaging techniques that aim to understand receptor localization and trafficking, techniques to measure receptor-ligand interactions, strategies to identify novel ligands and methods to analyze downstream receptor signaling, as well as strategies for genomic and proteomic characterization of receptor repertoires. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immune Receptors: Methods and Protocols offers technical descriptions and protocols that will be useful both to investigators who are interested in carrying out these procedures and to those who seek a deeper understanding of the bench science that lies behind the immunology literature.

Автор: P.L. Chambers; E. Cholnoky; C. Chambers
Название: Receptors and Other Targets for Toxic Substances
ISBN: 3540136703 ISBN-13(EAN): 9783540136705
Издательство: Springer
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Цена: 121110.00 T
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Автор: Marc Daeron; Falk Nimmerjahn
Название: Fc Receptors
ISBN: 3319379097 ISBN-13(EAN): 9783319379098
Издательство: Springer
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Цена: 130590.00 T
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Описание: Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection.

Автор: Steeve Herv? Thany
Название: Insect Nicotinic Acetylcholine Receptors
ISBN: 149395153X ISBN-13(EAN): 9781493951536
Издательство: Springer
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Цена: 130590.00 T
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Описание: This book investigates insect nicotinic acetylcholine receptors. It explores the involvement of insect nicotinic receptors in learning and memory processes, using the honeybee as insect model. The book a will serves as a useful guide to the field.

Автор: Bruce G. Allen; Terence E. H?bert
Название: Nuclear G-Protein Coupled Receptors
ISBN: 1493917544 ISBN-13(EAN): 9781493917549
Издательство: Springer
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Цена: 149060.00 T
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Описание: Nuclear G-Protein Coupled Receptors: Methods and Protocols is a compilation of a number of conceptual and methodological aspects important for the validation and characterization of intacrine signaling systems.

Автор: Richard Teke Ngomba; Giuseppe Di Giovanni; Giusepp
Название: mGLU Receptors
ISBN: 3319561685 ISBN-13(EAN): 9783319561684
Издательство: Springer
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Цена: 158380.00 T
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Описание: Metabotropic glutamate receptors (mGluRs) are members of the group C family of G-protein-coupled receptors. Eight different mGlu subtypes have been identified and classified into three groups based on amino acid sequence similarity, agonist pharmacology, and the signal transduction pathways to which they couple.

Автор: Marta Filizola
Название: G Protein-Coupled Receptors - Modeling and Simulation
ISBN: 9400774222 ISBN-13(EAN): 9789400774223
Издательство: Springer
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Цена: 148020.00 T
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Описание: G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses.

Автор: Anton G. Kutikhin; Arseniy E. Yuzhalin
Название: Genomics of Pattern Recognition Receptors
ISBN: 3034806876 ISBN-13(EAN): 9783034806879
Издательство: Springer
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Цена: 139310.00 T
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Описание: This book details the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, coverage examines the structure and function of Toll-like and NOD-like receptors.

Автор: Fridman
Название: Discoidin Domain Receptors in Health and Disease
ISBN: 1493963813 ISBN-13(EAN): 9781493963812
Издательство: Springer
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Цена: 156720.00 T
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Описание: The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease.

Автор: Reid Eric
Название: Investigation of Membrane-Located Receptors
ISBN: 1468446339 ISBN-13(EAN): 9781468446333
Издательство: Springer
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Цена: 113190.00 T
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Описание: But `Proceedings` are proverbially ephemeral material reflecting an array of solo performances, whereas this book is hopefully more like an orchestra`s performance, of classical together with new material. Related to receptor methodo- logy, receptor features and phenomena get due attention in the text.

Автор: Giuseppe Di Giovanni; Ennio Esposito; Vincenzo Di
Название: 5-HT2C Receptors in the Pathophysiology of CNS Disease
ISBN: 1617797200 ISBN-13(EAN): 9781617797200
Издательство: Springer
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Цена: 243800.00 T
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Описание: Increased understanding of the 5-HT2c receptor may play a key role in the treatment of many central nervous system diseases ranging from eating disorders and Parkinson`s to Alzheimer`s and epilepsy. This is the first ever overview of 5-HT2c receptor research.