mGLU Receptors, Richard Teke Ngomba; Giuseppe Di Giovanni; Giusepp

Автор: Francesco Clementi; Cecilia Gotti; Emanuele Sher
Название: Nicotinic Acetylcholine Receptors in the Nervous System
ISBN: 364274169X ISBN-13(EAN): 9783642741692
Издательство: Springer
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Цена: 121110.00 T
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Описание: Proceedings of the NATO Advanced Research Workshop on Nicotine Acetylcholine Receptors in the Nervous System held in Venice, Italy, April 18-21, 1988

Автор: Joan Heller Brown
Название: The Muscarinic Receptors
ISBN: 1461288479 ISBN-13(EAN): 9781461288473
Издательство: Springer
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Цена: 144410.00 T
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Описание: Research on muscarinic receptors is advancing at an extraordinary rate. The discovery that pirenzepine recognized apparent heterogeneity in muscarinic binding sites infused new life into the problem of subclassifying muscarinic receptors.

Автор: Elaine Sanders-Bush
Название: The Serotonin Receptors
ISBN: 1461289122 ISBN-13(EAN): 9781461289128
Издательство: Springer
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Цена: 144410.00 T
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Описание: Serotonin (5-HT) was isolated and chemically characterized nearly four decades ago, and is now generally accepted to function as a neurotransmitter and neuromodulatory agent. As the first of what we can expect to be a steady stream of monographs focusing on 5-HT receptors, the book confirms that we are in an exciting time in the history of 5-HT.

Автор: Lee E. Limbird
Название: The alpha-2 Adrenergic Receptors
ISBN: 1461289424 ISBN-13(EAN): 9781461289425
Издательство: Springer
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Цена: 144410.00 T
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Автор: Michael Williams
Название: Adenosine and Adenosine Receptors
ISBN: 1461288509 ISBN-13(EAN): 9781461288503
Издательство: Springer
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Цена: 55890.00 T
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Описание: Historically, the major emphasis on the study of purinergic systems has been predominantly in the areas of physiology and gross pharmacology. The last decade has seen an exponential in- crease in the number of publications related to the role of both adenosine and A TP in mammalian tissue function, a level of interest that has evolved from a more molecular focus on the identity of adenosine and A TP receptor subtypes and the search for selective ligands and development of radioligand binding assays by Fred Bruns and colleagues (especially that for A receptors) that played z a highly significant role in advancing research in the area. In the 60 years since adenosine was first shown to be a potent hypotensive agent, a considerable investment has been made by several pharmaceutical companies-including Abbott, Byk Gulden, Takeda, Warner-LambertlParke Davis, Boehringer Mann- heim, Boehringer Ingelheim, Nelson/Whitby Research and CffiA- Geigy-as well as John Daly's laboratory at the National Institutes of Health, to design new adenosine receptor ligands, and both agon- ists and antagonists with the aim of developing new therapeutic entiities. Numerous research tools have derived from these efforts including: 2-chloroadenosine, R-PIA ( -phenylisopropyladeno- sine; NECA (5' N-ethylcarboxamidoadenosine); CV1808; CI936; PD 125,944; -benzyladenosine; PACPX; CPX; CPT; XAC; CGS 15943 and CGS 21680. Yet in the realm of therapeutics it was only in 1989 that adenosine itself was approved for human use in the treatment of supraventricular arrythmias.

Автор: Chikako Tanaka; Norman G. Bowery
Название: GABA: Receptors, Transporters and Metabolism
ISBN: 3034898584 ISBN-13(EAN): 9783034898584
Издательство: Springer
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Цена: 97820.00 T
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Автор: Daniel Monaghan; Robert Wenthold
Название: The Ionotropic Glutamate Receptors
ISBN: 1461284422 ISBN-13(EAN): 9781461284420
Издательство: Springer
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Цена: 213360.00 T
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Описание: The field of the excitatory amino acids was born when L-glutamate and L-aspartate were found to be potent convulsants (Hayashi, 1954), and were subsequently found to excite neurons directly (Curtis, Phillis, and Watkins, 1959). Although these studies initiated the hypothesis of glutamate-mediated neurotransmission, it was noted that the ubiquitous actions of glutamate could also reflect a general, nonspecific property of glutamate on neuronal mem- branes. It was not until 20 years later that pharmacological, physiological, and biochemical studies provided convincing evidence for a neurotransmitter role for glutamate in the mammalian central nervous system (CNS). With the critical demonstration that the pharmacologically defined glutamate receptors mediate synaptic currents, glutamate rapidly became widely accepted as a majorneurotransmitter by the mid-1980s. This breakthrough, together with the simultaneous findings that glutamate receptors are involved in many essential, as well as pathological, processes in the CNS, instantly transformed the study of glutamate receptors into one of the fastest-growing and most exciting areas of neuroscience. With the cloning of numerous ionotropic glutamate receptor subunits over the last six years, the field has experienced another dramatic acceleration in the understanding of receptor action and in providing the first clear insights into the molecular bases underlying the wealth of pharmacological and physiological data on these receptors.

Автор: P. Jeffrey Conn; Jitendra Patel
Название: The Metabotropic Glutamate Receptors
ISBN: 1617370061 ISBN-13(EAN): 9781617370069
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Цена: 213360.00 T
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Описание: It is the goal of The Metabotropic Glutamate Receptors to provide acomprehensive and forward-thinking review ofthe tremen- dous advances that have occurred in less than a decade of metabotropic glutamate receptors (mGluR) research. Virtually every areaof mGluR research is covered, including the molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles of mGluRs. It is our intention that this volume not only summarize what is now known about the mGluRs, but also illuminate the areas in which there is the greatest need for focused research. Glutamic acid is an amino acid that has long been known to play several important metabolic roles in central and peripheral tissues and to be a component of several naturally occurring molecules. The first evidence that glutamate mayaIso serve as a neurotransmitter in the central nervous system (CNS) came in the late 1950s and early 1960s when glutamate and other acidic amino acids were found to induce behavioral convulsions when topically applied to the cortex and to excite a wide variety of central neurons. These findings spurred a massive research effort that quickly established glutamate as the pri- mary excitatory neurotransmitter in the vertebrate CNS. One of the most striking characteristics of glutamate that was quickly recognized was its ubiquitous role in serving as the neurotransmitter at the vast majority of excitatory synapses in the brain. It is now clear that most central neuronal circuits involve glutamatergic neurotransmission at some level.

Автор: Lee E. Limbird
Название: Cell Surface Receptors
ISBN: 1441935711 ISBN-13(EAN): 9781441935717
Издательство: Springer
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Цена: 121890.00 T
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Описание: Cell Surface Receptors: A Short Course on Theory and Methods, 3rd Edition, links theoretical insights into drug-receptor interactions described in mathematical models with the experimental strategies to characterize the biological receptor of interest.

Автор: Robin A.J. Lester
Название: Nicotinic Receptors
ISBN: 1493948598 ISBN-13(EAN): 9781493948598
Издательство: Springer
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Цена: 139310.00 T
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Описание: A comprehensive overview of nicotinic receptors that addresses their history from crystal structure to behavior as well as their implications in disease and potential as therapeutic targets.

Автор: Craig W. Stevens
Название: Methods for the Discovery and Characterization of G Protein-Coupled Receptors
ISBN: 1493958518 ISBN-13(EAN): 9781493958511
Издательство: Springer
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Цена: 135090.00 T
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Описание: This book presents the latest methods and technology used to characterize and discover novel mechanisms of G protein-coupled receptors (GPCRs) which, in many cases, can be used directly to design experiments for the reader`s particular GPCR of interest.

Автор: G. Csaba
Название: Development of Hormone Receptors
ISBN: 3034899823 ISBN-13(EAN): 9783034899826
Издательство: Springer
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Цена: 74490.00 T
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