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Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate, Israel A., Strooper B. de, Checler F., Christen Y.

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Цена: 105740T
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Наличие: Поставка под заказ.  Есть в наличии на складе поставщика.
Склад Англия: 5 шт.  Склад Америка: 79 шт.  
При оформлении заказа до: 1 фев 2019
Ориентировочная дата поставки: начало Марта

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Автор: Israel A., Strooper B. de, Checler F., Christen Y.
Название:  Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate
Издательство: Springer
Классификация:
Неврология и клиническая нейрофизиология
Биологические науки: общие вопросы

ISBN: 3540430733
ISBN-13(EAN): 9783540430735
ISBN: 3-540-43073-3
ISBN-13(EAN): 978-3-540-43073-5
Обложка/Формат: Hardback
Страницы: 158
Вес: 0.471 кг.
Дата издания: 2002
Серия: Research and Perspectives in Alzheimer's Disease
Иллюстрации: 1 black & white tables, biography
Размер: 235 x 155 x 11
Читательская аудитория: Professional & vocational
Рейтинг:
Поставляется из: Германии
Описание: Can molecular mechanisms involved in neural development help us to understand, prevent and perhaps reverse the course of brain ageing and neurodegenerative disorders? Brain development and function require complex cellular and molecular processes controlled by a number of different signaling mechanisms. One such signaling mechanism, the Notch pathway, has been recognized as an important player in the regulation of cellfate decisions during early neural development. However, the action of this evolutionary conserved and widely used cell-cell interaction mechanism is not confined to the developing nervous system. In addition, recent studies have shown that elucidating the mechanism of Notch signaling and its role in the brain is important for our understanding of neurological disorders such as Alzheimers disease and cerebral arteriopathy CADASIL.
Дополнительное описание: Формат: 235x155
Илюстрации: 32
Круг читателей: Researchers and scientists in the fields ofneurodegeneration and Alzheimer's disease
Ключевые слова: ALzheimer's Disease
Proteolysis
nicastrin
presenilin
ubiquitin-proteasome pathway
Язык: eng
Оглавление: Regulated intramembrane proteolysis - new lessons from lipid metabolism and the unfolded protein response.-Notch signaling in the brain: more than just a developmental story.-Control of notch activity by the ubiquitin-proteasome pathway.-A presenilin-dependent S3-like gamma-secretase cleavage of the beta-amyloid precursor protein.-New non-peptide inhibitors of gamma-secretase abolish A-beta production without modyfying notch cleavage.-Presenilins, APP, and notch: proteolysis from womb to tomb.-Missorting of the dendritic cell adhesion molecule telencephalin in presenilin-deficient neurons.-Beta-APP processing, its biology and Alzheimer's Disease.-Further analysis of the nicastrin: presenilin complex.-PS1 interacts with and facilitates beta-catenin turnover.-Delta-catenin, presenilin, and the synaptic-adherens junction complex.-Vascular smooth muscle cells are the primary target of the events leading from notch3 mutations to CADASIL.



Disease-Modifying Targets in Neurodegenerative Disorders

Автор: Baekelandt, Veerle
Название: Disease-Modifying Targets in Neurodegenerative Disorders
ISBN: 0128051205 ISBN-13(EAN): 9780128051207
Издательство: Elsevier Science
Рейтинг:
Цена: 40040 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies. . This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment.

Biometals in Neurodegenerative Diseases

Автор: White, Anthony R.
Название: Biometals in Neurodegenerative Diseases
ISBN: 0128045620 ISBN-13(EAN): 9780128045626
Издательство: Elsevier Science
Рейтинг:
Цена: 76800 T
Наличие на складе: Поставка под заказ.
Описание: Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer’s Disease, Parkinson’s Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. . This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases. . Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics.

Two Faces of Evil: Cancer and Neurodegeneration

Автор: Curran
Название: Two Faces of Evil: Cancer and Neurodegeneration
ISBN: 3642166016 ISBN-13(EAN): 9783642166013
Издательство: Springer
Рейтинг:
Цена: 127450 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes

The Proteasome in Neurodegeneration

Автор: Stefanis Leonidas, Keller J.N.
Название: The Proteasome in Neurodegeneration
ISBN: 0387284990 ISBN-13(EAN): 9780387284996
Издательство: Springer
Рейтинг:
Цена: 97390 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: There is increasing evidence that links together various common neurodegenerative diseases, such as Parkinson`s and Alzheimer`s diseases. Finding common themes in the pathophysiology of such disorders is increasingly important. This text addresses such a common theme - the proteasome.

Frontiers in Clinical Neuroscience / Neurodegeneration and Neuroprotection

Автор: Vecsei Laszlo
Название: Frontiers in Clinical Neuroscience / Neurodegeneration and Neuroprotection
ISBN: 0306480387 ISBN-13(EAN): 9780306480386
Издательство: Springer
Рейтинг:
Цена: 127450 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This is a special proceedings - "Frontiers in Clinical Neuroscience: 2002" - held in Abel Lajtha's honor. Professor Lajtha is a well-known supporter of Hungarian science and he is celebrating his 80th birthday this year. Professor Vecsei is the secretary for the European Society for Clinical Neuropharmacology and the Danube Symposium for Neurological Sciences. The proceedings will focus on neurodegeneration and neuroprotection, two current topics in clinical and experimental neuroscience.

Neurodegeneration in Multiple Sclerosis

Автор: Filippi
Название: Neurodegeneration in Multiple Sclerosis
ISBN: 8847003903 ISBN-13(EAN): 9788847003903
Издательство: Springer
Цена: 94610 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In multiple sclerosis (MS), conventional magnetic resonance imaging (cMRI) has proved to be a valuable tool to increase diagnostic confidence and for monitoring the efficacy of experimental treatment. However, cMRI has limited specificity and accuracy of cMRI to the most disabling aspects of the MS pathology, known to occur in and outside macroscopic lesions. Modern quantitative MR techniques have the potential to overcome the limitations of cMRI, and their application is changing dramatically our understanding of how MS causes irreversible disability. In detail, there is an increasing body of MR evidence that MS is not only a white matter disease and does not only cause focal lesions, as well as that neurodegeneration is an important aspect of the disease (since the earliest clinical phases), which is only partially related to inflammatory changes. There is also increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it will bi and indispensable tool for all those working in this field.

Neurodegeneration and Prion Disease

Автор: Brown David R.
Название: Neurodegeneration and Prion Disease
ISBN: 0387239227 ISBN-13(EAN): 9780387239224
Издательство: Springer
Рейтинг:
Цена: 104020 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides an in-depth overview from world experts on prion disease. These fatal diseases include Creutzfeldt-Jakob disease, chronic wasting disease in deer, scrapie of sheep, bovine spongiform encephalopathy (mad cow’s disease) of cattle and related diseases. Understanding what causes neuronal death in these diseases is essential to both preventing and curing them. The most recent advances in understanding neuronal death in prion diseases are presented. Prion diseases serve as an experimental model for all neurodegenerative conditions. This book will provide understanding of neurodegeneration and provide an up-to-date record of the state of the art for other specialists and non-specialists in related fields.

Congenital Heart Disease and Neurodevelopment

Автор: McCusker, Christopher
Название: Congenital Heart Disease and Neurodevelopment
ISBN: 012801640X ISBN-13(EAN): 9780128016404
Издательство: Elsevier Science
Рейтинг:
Цена: 40040 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: . Congenital Heart Disease and Neurodevelopment: Understanding and Improving Outcomes brings together the work of leading researchers from the U.K., Europe, and the U.S. to provide a comprehensive examination of the causes, risks, and neurodevelopmental and psychological outcomes in children with congenital heart disease. The book includes longitudinal studies which have tracked outcomes from birth through late childhood and explores the emergent phenotype and etiologies, risk, and protective factors that strengthen proposed models. . Medical and surgical advances have meant that greater numbers of children with even the most severe congenital heart disease (CHD) now survive well into adulthood. Studies over the past 20 years have suggested certain neurodevelopmental and psychological features are common, with clinical interventions being internationally articulated. The U.K. Belfast Center has developed and evaluated unique early intervention programs to circumvent the common problems discerned and promote optimal adjustment and outcomes. The first edition of Congenital Heart Disease and Neurodevelopment: Understanding and Improving Outcomes describes these programs in detail and outlines promising results obtained by researchers worldwide. Such interventions, together with the U.S. consensus statement (Circulation, 2012) on neurodevelopmental screening, hold great promise for clinical interventions.

Thyroid Hormone Disruption and Neurodevelopment

Автор: Noriyuki Koibuchi; Paul M. Yen
Название: Thyroid Hormone Disruption and Neurodevelopment
ISBN: 1493937359 ISBN-13(EAN): 9781493937356
Издательство: Springer
Рейтинг:
Цена: 88420 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood. ?

The Benefits of Natural Products for Neurodegenerative Diseases

Автор: Essa
Название: The Benefits of Natural Products for Neurodegenerative Diseases
ISBN: 3319283812 ISBN-13(EAN): 9783319283814
Издательство: Springer
Рейтинг:
Цена: 88420 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

Intracellular Traffic and Neurodegenerative Disorders

Автор: Peter H. St.George-Hyslop; William C. Mobley; Yves
Название: Intracellular Traffic and Neurodegenerative Disorders
ISBN: 3540879404 ISBN-13(EAN): 9783540879404
Издательство: Springer
Рейтинг:
Цена: 116320 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them.

Neurodegenerative Diseases

Автор: Galimberti Daniela
Название: Neurodegenerative Diseases
ISBN: 1447163796 ISBN-13(EAN): 9781447163794
Издательство: Springer
Рейтинг:
Цена: 66780 T
Наличие на складе: Поставка под заказ.
Описание: This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer`s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases.


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