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Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate, Israel A., Strooper B. de, Checler F., Christen Y.

Автор: Israel A., Strooper B. de, Checler F., Christen Y.
Название:  Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate
Издательство: Springer
Классификация:
Неврология и клиническая нейрофизиология
Биологические науки: общие вопросы

ISBN: 3540430733
ISBN-13(EAN): 9783540430735
ISBN: 3-540-43073-3
ISBN-13(EAN): 978-3-540-43073-5
Обложка/Формат: Hardback
Страницы: 158
Вес: 0.471 кг.
Дата издания: 2002
Серия: Research and Perspectives in Alzheimer's Disease
Иллюстрации: 1 black & white tables, biography
Размер: 235 x 155 x 11
Читательская аудитория: Professional & vocational
Рейтинг:
Поставляется из: Германии
Описание: Can molecular mechanisms involved in neural development help us to understand, prevent and perhaps reverse the course of brain ageing and neurodegenerative disorders? Brain development and function require complex cellular and molecular processes controlled by a number of different signaling mechanisms. One such signaling mechanism, the Notch pathway, has been recognized as an important player in the regulation of cellfate decisions during early neural development. However, the action of this evolutionary conserved and widely used cell-cell interaction mechanism is not confined to the developing nervous system. In addition, recent studies have shown that elucidating the mechanism of Notch signaling and its role in the brain is important for our understanding of neurological disorders such as Alzheimers disease and cerebral arteriopathy CADASIL.
Дополнительное описание: Формат: 235x155
Илюстрации: 32
Круг читателей: Researchers and scientists in the fields ofneurodegeneration and Alzheimer's disease
Ключевые слова: ALzheimer's Disease
Proteolysis
nicastrin
presenilin
ubiquitin-proteasome pathway
Язык: eng
Оглавление: Regulated intramembrane proteolysis - new lessons from lipid metabolism and the unfolded protein response.-Notch signaling in the brain: more than just a developmental story.-Control of notch activity by the ubiquitin-proteasome pathway.-A presenilin-dependent S3-like gamma-secretase cleavage of the beta-amyloid precursor protein.-New non-peptide inhibitors of gamma-secretase abolish A-beta production without modyfying notch cleavage.-Presenilins, APP, and notch: proteolysis from womb to tomb.-Missorting of the dendritic cell adhesion molecule telencephalin in presenilin-deficient neurons.-Beta-APP processing, its biology and Alzheimer's Disease.-Further analysis of the nicastrin: presenilin complex.-PS1 interacts with and facilitates beta-catenin turnover.-Delta-catenin, presenilin, and the synaptic-adherens junction complex.-Vascular smooth muscle cells are the primary target of the events leading from notch3 mutations to CADASIL.


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Disease-Modifying Targets in Neurodegenerative Disorders

Автор: Baekelandt, Veerle
Название: Disease-Modifying Targets in Neurodegenerative Disorders
ISBN: 0128051205 ISBN-13(EAN): 9780128051207
Издательство: Elsevier Science
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Цена: 40040 T
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Описание:

Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies.

This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment.

  • Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress
  • Summarizes how patients are treated today, providing a glance at future disease management
  • Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists
  • Written and peer reviewed by outstanding scientists in their respective fields

Biometals in Neurodegenerative Diseases

Автор: White, Anthony R.
Название: Biometals in Neurodegenerative Diseases
ISBN: 0128045620 ISBN-13(EAN): 9780128045626
Издательство: Elsevier Science
Рейтинг:
Цена: 76800 T
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Описание:

Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer's Disease, Parkinson's Disease, Motor Neuron Disease, Autism and lysosomal storage disorders.

This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases.

Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics.

  • Authoritative and timely resource bringing together the major findings in the field for those with an interest in metals and their role in the brain function, disease, and as therapeutic targets
  • Written for academic researchers, clinicians, and advanced graduate students studying, or treating, patients in neurodegeneration, neurochemistry, neurology and neurotoxicology
  • Edited by international leaders in the field who have contributed greatly to the study of metals in neurodegenerative diseases

Neurodegenerative Diseases

Автор: Galimberti Daniela
Название: Neurodegenerative Diseases
ISBN: 1447163796 ISBN-13(EAN): 9781447163794
Издательство: Springer
Рейтинг:
Цена: 66780 T
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Описание: This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer`s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases.

Protein chaperones and protection from neurodegenerative diseases

Название: Protein chaperones and protection from neurodegenerative diseases
ISBN: 0470569077 ISBN-13(EAN): 9780470569078
Издательство: Wiley
Рейтинг:
Цена: 77760 T
Наличие на складе: Поставка под заказ.
Описание: How protein chaperones protect cells from neurodegenerative diseases Including contributions from leading experts, Protein Chaperones and Protection from Neurodegenerative Diseases provides an in-depth exploration of how protein chaperones are involved

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases

Название: Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases
ISBN: 144196651X ISBN-13(EAN): 9781441966513
Издательство: Springer
Рейтинг:
Цена: 114430 T
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Описание: Neurodegenerative diseases are characterized by chronic and progressive loss of neurons in discrete areas of the brain. This book presents cutting-edge, comprehensive information on the molecular aspects of acute neural trauma and neurodegenerative diseases.

Genotype - Proteotype - Phenotype Relationships in Neurodegenerative Diseases

Автор: Cummings J., Hardy J., Poncet M., Christen Yves
Название: Genotype - Proteotype - Phenotype Relationships in Neurodegenerative Diseases
ISBN: 3540248358 ISBN-13(EAN): 9783540248354
Издательство: Springer
Рейтинг:
Цена: 127450 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Recent advances in understanding the role of protein dysmetabolism in neurodegeneration was the theme of the Fondation IPSEN meeting addressing Genotype-Proteotype-Phenotype relationships. Experts from international laboratories contributed to the  current volume to produce a comprehensive overview of the role of protein misfolding in neurodegeneration. Links between genotype and protein characteristics and between proteotype and clinical phenomenology were discussed across diseases categories. Progress in understanding the role of abnormalities of protein metabolism may lead to the identification of biological markers relevant to disease monitoring and to the development of new therapeutic agents capable of modifying and ameliorating basic neurodegenerative mechanisms.

Pathogenesis of Neurodegenerative Disorders

Автор: Mattson Mark P.
Название: Pathogenesis of Neurodegenerative Disorders
ISBN: 0896038386 ISBN-13(EAN): 9780896038387
Издательство: Springer
Рейтинг:
Цена: 114430 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this groundbreaking book, leading experts detail the cellular and molecular cascades that cause selective degeneration of neuronal populations, and illuminate those genetic and environmental factors that are critical to the facilitation or suppression of the neuropathologic processes. Working from studies of human patients, as well as from cell culture and animal models, the authors demonstrate a heretofore unrecognized convergence of the causative pathogenetic mechanisms for clinically distinct neurological disorders. At center stage are the biochemical and molecular cascades that will ultimately lead to neuronal death-cascades involving oxyradical production, aberrant regulation of cellular ion homeostasis, activation of specific proteases, and activation of a stereotyped sequence of events involving mitochondial dysfunction. Individual chapters examine how these mechanisms-along with genetic and environmental factors-operate in Alzheimer's and Parkinson's diseases, Down's syndrome, amyotropic lateral sclerosis, ischemic stroke, spinal cord injury, and Duchenne muscular dystrophy.

Role of Proteases in the Pathophysiology of Neurodegenerative Diseases

Автор: Lajtha Abel, Banik Naren L.
Название: Role of Proteases in the Pathophysiology of Neurodegenerative Diseases
ISBN: 0306465795 ISBN-13(EAN): 9780306465796
Издательство: Springer
Рейтинг:
Цена: 88420 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book looks at the role of proteases, which are enzymes that digest proteins, and the various roles that proteases play in the development of neurodegenerative diseases such as Alzheimer's disease, ALS, epilepsy, multiple sclerosis, as well as numerous other neuromuscular diseases.

Neurodegenerative Disorders: Loss of Function Through Gain of Function

Автор: Beyreuther K., Christen Y., Masters C.L.
Название: Neurodegenerative Disorders: Loss of Function Through Gain of Function
ISBN: 3540412182 ISBN-13(EAN): 9783540412182
Издательство: Springer
Рейтинг:
Цена: 91830 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The main message from this book is that different protein aggregation processes may all be amenable to a small number of intervention steps based on a common theme of the modulation of production, turnover and deposition of the corresponding disease gene products.

The Proteasome in Neurodegeneration

Автор: Stefanis Leonidas, Keller J.N.
Название: The Proteasome in Neurodegeneration
ISBN: 0387284990 ISBN-13(EAN): 9780387284996
Издательство: Springer
Рейтинг:
Цена: 97390 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: There is increasing evidence that links together various common neurodegenerative diseases, such as Parkinson`s and Alzheimer`s diseases. Finding common themes in the pathophysiology of such disorders is increasingly important. This text addresses such a common theme - the proteasome.

Frontiers in Clinical Neuroscience / Neurodegeneration and Neuroprotection

Автор: Vecsei Laszlo
Название: Frontiers in Clinical Neuroscience / Neurodegeneration and Neuroprotection
ISBN: 0306480387 ISBN-13(EAN): 9780306480386
Издательство: Springer
Рейтинг:
Цена: 127450 T
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Описание: This is a special proceedings - "Frontiers in Clinical Neuroscience: 2002" - held in Abel Lajtha's honor. Professor Lajtha is a well-known supporter of Hungarian science and he is celebrating his 80th birthday this year. Professor Vecsei is the secretary for the European Society for Clinical Neuropharmacology and the Danube Symposium for Neurological Sciences. The proceedings will focus on neurodegeneration and neuroprotection, two current topics in clinical and experimental neuroscience.

Two Faces of Evil: Cancer and Neurodegeneration

Автор: Curran
Название: Two Faces of Evil: Cancer and Neurodegeneration
ISBN: 3642166016 ISBN-13(EAN): 9783642166013
Издательство: Springer
Рейтинг:
Цена: 127450 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes


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