Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies.
This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment.
Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress
Summarizes how patients are treated today, providing a glance at future disease management
Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists
Written and peer reviewed by outstanding scientists in their respective fields
Автор: White, Anthony R. Название: Biometals in Neurodegenerative Diseases ISBN: 0128045620 ISBN-13(EAN): 9780128045626 Издательство: Elsevier Science Рейтинг: Цена: 76800 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer's Disease, Parkinson's Disease, Motor Neuron Disease, Autism and lysosomal storage disorders.
This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases.
Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics.
Authoritative and timely resource bringing together the major findings in the field for those with an interest in metals and their role in the brain function, disease, and as therapeutic targets
Written for academic researchers, clinicians, and advanced graduate students studying, or treating, patients in neurodegeneration, neurochemistry, neurology and neurotoxicology
Edited by international leaders in the field who have contributed greatly to the study of metals in neurodegenerative diseases
Автор: Galimberti Daniela Название: Neurodegenerative Diseases ISBN: 1447163796 ISBN-13(EAN): 9781447163794 Издательство: Springer Рейтинг: Цена: 66780 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer`s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases.
Название: Protein chaperones and protection from neurodegenerative diseases ISBN: 0470569077 ISBN-13(EAN): 9780470569078 Издательство: Wiley Рейтинг: Цена: 77760 T Наличие на складе: Поставка под заказ. Описание: How protein chaperones protect cells from neurodegenerative diseases Including contributions from leading experts, Protein Chaperones and Protection from Neurodegenerative Diseases provides an in-depth exploration of how protein chaperones are involved
Название: Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases ISBN: 144196651X ISBN-13(EAN): 9781441966513 Издательство: Springer Рейтинг: Цена: 114430 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Neurodegenerative diseases are characterized by chronic and progressive loss of neurons in discrete areas of the brain. This book presents cutting-edge, comprehensive information on the molecular aspects of acute neural trauma and neurodegenerative diseases.
Автор: Cummings J., Hardy J., Poncet M., Christen Yves Название: Genotype - Proteotype - Phenotype Relationships in Neurodegenerative Diseases ISBN: 3540248358 ISBN-13(EAN): 9783540248354 Издательство: Springer Рейтинг: Цена: 127450 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Recent advances in understanding the role of protein dysmetabolism in neurodegeneration was the theme of the Fondation IPSEN meeting addressing Genotype-Proteotype-Phenotype relationships. Experts from international laboratories contributed to the current volume to produce a comprehensive overview of the role of protein misfolding in neurodegeneration. Links between genotype and protein characteristics and between proteotype and clinical phenomenology were discussed across diseases categories. Progress in understanding the role of abnormalities of protein metabolism may lead to the identification of biological markers relevant to disease monitoring and to the development of new therapeutic agents capable of modifying and ameliorating basic neurodegenerative mechanisms.
Автор: Mattson Mark P. Название: Pathogenesis of Neurodegenerative Disorders ISBN: 0896038386 ISBN-13(EAN): 9780896038387 Издательство: Springer Рейтинг: Цена: 114430 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In this groundbreaking book, leading experts detail the cellular and molecular cascades that cause selective degeneration of neuronal populations, and illuminate those genetic and environmental factors that are critical to the facilitation or suppression of the neuropathologic processes. Working from studies of human patients, as well as from cell culture and animal models, the authors demonstrate a heretofore unrecognized convergence of the causative pathogenetic mechanisms for clinically distinct neurological disorders. At center stage are the biochemical and molecular cascades that will ultimately lead to neuronal death-cascades involving oxyradical production, aberrant regulation of cellular ion homeostasis, activation of specific proteases, and activation of a stereotyped sequence of events involving mitochondial dysfunction. Individual chapters examine how these mechanisms-along with genetic and environmental factors-operate in Alzheimer's and Parkinson's diseases, Down's syndrome, amyotropic lateral sclerosis, ischemic stroke, spinal cord injury, and Duchenne muscular dystrophy.
Автор: Lajtha Abel, Banik Naren L. Название: Role of Proteases in the Pathophysiology of Neurodegenerative Diseases ISBN: 0306465795 ISBN-13(EAN): 9780306465796 Издательство: Springer Рейтинг: Цена: 88420 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book looks at the role of proteases, which are enzymes that digest proteins, and the various roles that proteases play in the development of neurodegenerative diseases such as Alzheimer's disease, ALS, epilepsy, multiple sclerosis, as well as numerous other neuromuscular diseases.
Автор: Beyreuther K., Christen Y., Masters C.L. Название: Neurodegenerative Disorders: Loss of Function Through Gain of Function ISBN: 3540412182 ISBN-13(EAN): 9783540412182 Издательство: Springer Рейтинг: Цена: 91830 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The main message from this book is that different protein aggregation processes may all be amenable to a small number of intervention steps based on a common theme of the modulation of production, turnover and deposition of the corresponding disease gene products.
Автор: Stefanis Leonidas, Keller J.N. Название: The Proteasome in Neurodegeneration ISBN: 0387284990 ISBN-13(EAN): 9780387284996 Издательство: Springer Рейтинг: Цена: 97390 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: There is increasing evidence that links together various common neurodegenerative diseases, such as Parkinson`s and Alzheimer`s diseases. Finding common themes in the pathophysiology of such disorders is increasingly important. This text addresses such a common theme - the proteasome.
Автор: Vecsei Laszlo Название: Frontiers in Clinical Neuroscience / Neurodegeneration and Neuroprotection ISBN: 0306480387 ISBN-13(EAN): 9780306480386 Издательство: Springer Рейтинг: Цена: 127450 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This is a special proceedings - "Frontiers in Clinical Neuroscience: 2002" - held in Abel Lajtha's honor. Professor Lajtha is a well-known supporter of Hungarian science and he is celebrating his 80th birthday this year. Professor Vecsei is the secretary for the European Society for Clinical Neuropharmacology and the Danube Symposium for Neurological Sciences. The proceedings will focus on neurodegeneration and neuroprotection, two current topics in clinical and experimental neuroscience.
Автор: Curran Название: Two Faces of Evil: Cancer and Neurodegeneration ISBN: 3642166016 ISBN-13(EAN): 9783642166013 Издательство: Springer Рейтинг: Цена: 127450 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes
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