Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate, Israel A., Strooper B. de, Checler F., Christen Y.
Автор: Baekelandt, Veerle Название: Disease-Modifying Targets in Neurodegenerative Disorders ISBN: 0128051205 ISBN-13(EAN): 9780128051207 Издательство: Elsevier Science Рейтинг: Цена: 40040 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies. . This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment.
Автор: White, Anthony R. Название: Biometals in Neurodegenerative Diseases ISBN: 0128045620 ISBN-13(EAN): 9780128045626 Издательство: Elsevier Science Рейтинг: Цена: 76800 T Наличие на складе: Поставка под заказ. Описание: Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer’s Disease, Parkinson’s Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. . This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases. . Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics.
Автор: Curran Название: Two Faces of Evil: Cancer and Neurodegeneration ISBN: 3642166016 ISBN-13(EAN): 9783642166013 Издательство: Springer Рейтинг: Цена: 127450 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes
Автор: Stefanis Leonidas, Keller J.N. Название: The Proteasome in Neurodegeneration ISBN: 0387284990 ISBN-13(EAN): 9780387284996 Издательство: Springer Рейтинг: Цена: 97390 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: There is increasing evidence that links together various common neurodegenerative diseases, such as Parkinson`s and Alzheimer`s diseases. Finding common themes in the pathophysiology of such disorders is increasingly important. This text addresses such a common theme - the proteasome.
Автор: Vecsei Laszlo Название: Frontiers in Clinical Neuroscience / Neurodegeneration and Neuroprotection ISBN: 0306480387 ISBN-13(EAN): 9780306480386 Издательство: Springer Рейтинг: Цена: 127450 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This is a special proceedings - "Frontiers in Clinical Neuroscience: 2002" - held in Abel Lajtha's honor. Professor Lajtha is a well-known supporter of Hungarian science and he is celebrating his 80th birthday this year. Professor Vecsei is the secretary for the European Society for Clinical Neuropharmacology and the Danube Symposium for Neurological Sciences. The proceedings will focus on neurodegeneration and neuroprotection, two current topics in clinical and experimental neuroscience.
Автор: Filippi Название: Neurodegeneration in Multiple Sclerosis ISBN: 8847003903 ISBN-13(EAN): 9788847003903 Издательство: Springer Цена: 94610 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In multiple sclerosis (MS), conventional magnetic resonance imaging (cMRI) has proved to be a valuable tool to increase diagnostic confidence and for monitoring the efficacy of experimental treatment. However, cMRI has limited specificity and accuracy of cMRI to the most disabling aspects of the MS pathology, known to occur in and outside macroscopic lesions. Modern quantitative MR techniques have the potential to overcome the limitations of cMRI, and their application is changing dramatically our understanding of how MS causes irreversible disability. In detail, there is an increasing body of MR evidence that MS is not only a white matter disease and does not only cause focal lesions, as well as that neurodegeneration is an important aspect of the disease (since the earliest clinical phases), which is only partially related to inflammatory changes. There is also increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it will bi and indispensable tool for all those working in this field.
Автор: Brown David R. Название: Neurodegeneration and Prion Disease ISBN: 0387239227 ISBN-13(EAN): 9780387239224 Издательство: Springer Рейтинг: Цена: 104020 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume provides an in-depth overview from world experts on prion disease. These fatal diseases include Creutzfeldt-Jakob disease, chronic wasting disease in deer, scrapie of sheep, bovine spongiform encephalopathy (mad cowвЂ™s disease) of cattle and related diseases. Understanding what causes neuronal death in these diseases is essential to both preventing and curing them. The most recent advances in understanding neuronal death in prion diseases are presented. Prion diseases serve as an experimental model for all neurodegenerative conditions. This book will provide understanding of neurodegeneration and provide an up-to-date record of the state of the art for other specialists and non-specialists in related fields.
Автор: McCusker, Christopher Название: Congenital Heart Disease and Neurodevelopment ISBN: 012801640X ISBN-13(EAN): 9780128016404 Издательство: Elsevier Science Рейтинг: Цена: 40040 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: . Congenital Heart Disease and Neurodevelopment: Understanding and Improving Outcomes brings together the work of leading researchers from the U.K., Europe, and the U.S. to provide a comprehensive examination of the causes, risks, and neurodevelopmental and psychological outcomes in children with congenital heart disease. The book includes longitudinal studies which have tracked outcomes from birth through late childhood and explores the emergent phenotype and etiologies, risk, and protective factors that strengthen proposed models. . Medical and surgical advances have meant that greater numbers of children with even the most severe congenital heart disease (CHD) now survive well into adulthood. Studies over the past 20 years have suggested certain neurodevelopmental and psychological features are common, with clinical interventions being internationally articulated. The U.K. Belfast Center has developed and evaluated unique early intervention programs to circumvent the common problems discerned and promote optimal adjustment and outcomes. The first edition of Congenital Heart Disease and Neurodevelopment: Understanding and Improving Outcomes describes these programs in detail and outlines promising results obtained by researchers worldwide. Such interventions, together with the U.S. consensus statement (Circulation, 2012) on neurodevelopmental screening, hold great promise for clinical interventions.
Автор: Noriyuki Koibuchi; Paul M. Yen Название: Thyroid Hormone Disruption and Neurodevelopment ISBN: 1493937359 ISBN-13(EAN): 9781493937356 Издательство: Springer Рейтинг: Цена: 88420 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood. ?
Автор: Essa Название: The Benefits of Natural Products for Neurodegenerative Diseases ISBN: 3319283812 ISBN-13(EAN): 9783319283814 Издательство: Springer Рейтинг: Цена: 88420 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.
Автор: Peter H. St.George-Hyslop; William C. Mobley; Yves Название: Intracellular Traffic and Neurodegenerative Disorders ISBN: 3540879404 ISBN-13(EAN): 9783540879404 Издательство: Springer Рейтинг: Цена: 116320 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them.
Автор: Galimberti Daniela Название: Neurodegenerative Diseases ISBN: 1447163796 ISBN-13(EAN): 9781447163794 Издательство: Springer Рейтинг: Цена: 66780 T Наличие на складе: Поставка под заказ. Описание: This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer`s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases.
Казахстан, 010000 Астана р-он Сарыарка, ул. Московская, д. 40, офис 425 ТОО "Логобук" Тел:+7(7172) 49-21-32, +7(707) 857-29-98 www.logobook.kz